Structural Studies of Infectious Disease Targets
We investigate viral proteins involved in infection and replication, as well as host–virus interaction proteins that contribute to pathogenic processes. Through structural and mechanistic analyses, we aim to understand how these biomolecules function and to identify targets relevant to therapeutic intervention.
- Viral proteins involved in infection and replication
- Host–virus interaction proteins
- Mechanistic structural analysis
Structure-based Antiviral Discovery
We apply structure-based approaches to the discovery and optimization of antiviral agents against viral proteins. Our strategy combines virtual screening, molecular dynamics-guided refinement, and biochemical characterization to evaluate inhibitor binding, activity, and mechanism of action.
- Structure-based design against viral proteins
- Virtual screening and MD-guided optimization
- Enzyme kinetics and mechanism-of-action studies
De Novo Design of Antiviral Binders and Antigens
We pursue the de novo design of protein binders that recognize viral targets and the design of antigens for infectious disease applications. By integrating AI-assisted modeling and computational optimization, we aim to generate proteins with improved recognition, stability, and functional performance.
- De novo design of protein binders to viral targets
- AI-guided antigen design