Laboratory
for Biomolecular Structure
Infectious Diseases Therapeutic Research Center
Therapeutics & Biotechnology Division
Korea Research Institute of Chemical Technology (KRICT)
The Laboratory for Biomolecular Structure (LBMS) investigates the structures and molecular mechanisms of biomolecules relevant to infectious diseases. We aim to identify therapeutic targets and support drug discovery through structural biology and integrative molecular analysis.
Our research combines X-ray crystallography, cryo-EM, and computational approaches, including AI-assisted analysis, virtual screening, and molecular dynamics simulations, to advance therapeutic strategies for infectious diseases.
Research Focus
Our research integrates structural biology, antiviral discovery, and protein engineering to advance therapeutic strategies for infectious diseases.
Structural Studies of Infectious Disease Targets
- Viral proteins involved in infection and replication
- Host–virus interaction proteins
- Mechanistic structural analysis
Structure-based Antiviral Discovery
- Structure-based design against viral proteins
- Virtual screening and MD-guided optimization
- Enzyme kinetics and mechanism-of-action studies
AI-based Protein Design
- De novo design of protein binders to viral targets
- AI-guided antigen design